2026 / PREPRINT
69. Tumor-Associated Macrophages Promote Brain Metastasis.
bioRxiv · 2026 · Preprint
* co-corresponding authors
We use Drosophila models to investigate the cellular and organismal consequences of human disease. Our work connects genetic perturbations with developmental, behavioral, and systemic phenotypes, including centrosome-related disorders and cancer.
We have developed Autobehaver, a high-throughput platform that combines scalable recording hardware with Transformer-based machine learning to quantify Drosophila behavior.
From disease models to quantitative phenotypes
Autobehaver transforms raw video into profiles of movement and orientation, allowing us to identify subtle phenotypic signatures in human disease models. This approach supports studies of the neural and genetic basis of complex disorders and provides a foundation for future genetic and chemical suppressor screens.
Selected publications
2026 / PREPRINT
68. Autobehaver: An AI-Based Pipeline for Animal Behavior Analysis.
bioRxiv · 2026 · Preprint
* co-corresponding authors
2026 / PREPRINT
70. A MOPD II-associated Pericentrin variant disrupts PACT domain dimerization and pericentriolar material recruitment.
bioRxiv · Preprint
# co-first authors
2024
54. Using Drosophila to Uncover the Role of Organismal Physiology and the Tumor-Microenvironment in Cancer
Trends Cancer · 2024; 10(4): 289-311
(* co-corresponding)
★ Featured article · Trends in Cancer
2021
48. Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
EMBO J · 2021; 40(18): e107336
