Centrosomes for Spindle Assembly

As the cornerstones of the bipolar mitotic spindle, the centrosomes ensure efficient and accurate chromosome attachment and segregation. I have had a longstanding interested in spindle assembly, with particular focus on the role of centrosomal microtubules (MTs), MT dynamics, pole focusing,  and MT motors. We are interested in identifying common and unique mechanisms between symmetric and asymmetric cell divisions.

  

Recently, my lab has been interested in the role of Asp (Abnormal Spindle) and Cam (Calmodulin) in spindle assembly. Their role in spindle pole focusing truly highlights the cell-type diversity in tolerance to spindle assembly defects. We are currently exploring Asp as a model for microcephaly by investigating both its mitotic spindle dependent and independent roles.